Tg(Il9-cre)#Stck
Transgene Detail
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| Symbol: |
Tg(Il9-cre)#Stck |
| Name: |
transgene insertion, Brigitta Stockinger |
| MGI ID: |
MGI:5296240 |
| Synonyms: |
Il9Cre |
| Transgene: |
Tg(Il9-cre)#Stck Location: unknown
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| Alliance: |
Tg(Il9-cre)#Stck page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Il9-cre)#Stck expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Il9 (MGI:96563) |
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Mutation details: A targeting construct containing a cre-IRES-mCherry sequence was inserted upstream of the ATG translation initiation site of Il9 via homologous recombination into a BAC clone (RP24-282A18). The recombined BAC was injected into fertilized (CBA x B10)F1 oocytes. Analyses of T cells isolated from crosses to ROSA26-EYFP mice identified only 10% of Il9-producing cells were marked by EYFP. It was discovered that the IRES and mCherry in the construct was disabled because of a premature translational start site in the IRES sequence which possibly diminished activity from the ATG of mCherry sequence.
(J:177640)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Il9
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:177640 Wilhelm C, et al., An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol. 2011;12(11):1071-7 |
| All: |
2 reference(s) |
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Analysis Tools
