Aire<tm1.1(cre)Ghr> Targeted Allele Detail MGI Mouse (MGI:5296650)

Aire^{tm1.1(cre)Ghr}
Targeted Allele Detail

Summary

Symbol:	Aire^{tm1.1(cre)Ghr}
Name:	autoimmune regulator; targeted mutation 1.1, Georg A Hollander
MGI ID:	MGI:5296650
Gene:	Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
Alliance:	Aire^{tm1.1(cre)Ghr} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:176844
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Aire^{tm1.1(cre)Ghr} expression driven by 1 gene

Mutation details: A cassette composed of an NLS-cre, an IRES-GFP, and an FRT flanked PGK-neomycin replaced exon 1. Flp mediated deletion in-vivo removed the neo selection cassette. (J:176844)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (mouse) Summary of all recombinase alleles driven by Aire. Alliance mouse Aire gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Aire Mutation:	52 strains or lines available

References

Original:	J:176844 Lei Y, et al., Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med. 2011 Feb 14;208(2):383-94
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24