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Men1tm2.1Mmey
Targeted Allele Detail
Summary
Symbol: Men1tm2.1Mmey
Name: multiple endocrine neoplasia 1; targeted mutation 2.1, Matthew Meyerson
MGI ID: MGI:5296656
Synonyms: Men1f, Men1lox
Gene: Men1  Location: Chr19:6385009-6390921 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Alliance: Men1tm2.1Mmey page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88588
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 3 through 6 floxed. This allele was used to generate Men1tm1Mmey. (J:88588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Men1tm2.1Mmey
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  40 strains or lines available
References
Original:  J:88588 Hughes CM, et al., Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell. 2004 Mar 27;13(4):587-97
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
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