Pglyrp4tm1Rdz
Targeted Allele Detail
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|
| Symbol: |
Pglyrp4tm1Rdz |
| Name: |
peptidoglycan recognition protein 4; targeted mutation 1, Roman Dziarski |
| MGI ID: |
MGI:5297107 |
| Gene: |
Pglyrp4 Location: Chr3:90634213-90648824 bp, + strand Genetic Position: Chr3, 39.96 cM, cytoband F1
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| Alliance: |
Pglyrp4tm1Rdz page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:178054
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| Parent Cell Line: |
iTL1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 3 and 4 were replaced with a neo cassette. Quantitative RT-PCR confirmed the absence of transcript expression.
(J:178054)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | | | | | involves: 129S6/SvEvTac * BALB/c | |
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| Phenotypes: |
| Affected Systems |
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cardiovascular system
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√
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gastrointestinal hemorrhage
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√
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cellular
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√
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abnormal intestinal goblet cell morphology
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√
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digestive/alimentary system
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√
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gastrointestinal hemorrhage
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√
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abnormal intestinal epithelium morphology
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√
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abnormal intestinal mucosa morphology
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√
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abnormal intestinal goblet cell morphology
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√
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abnormal crypts of Lieberkuhn morphology
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√
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intestinal ulcer
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√
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abnormal gut flora balance
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√
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increased susceptibility to induced colitis
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√
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endocrine/exocrine glands
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√
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abnormal crypts of Lieberkuhn morphology
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√
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growth/size/body
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√
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weight loss
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√
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homeostasis/metabolism
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√
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increased susceptibility to xenobiotic induced morbidity/mortality
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√
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immune system
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N
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√
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immune system phenotype
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N
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increased susceptibility to induced colitis
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√
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abnormal chemokine secretion
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√
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increased interleukin-6 secretion
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√
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mortality/aging
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√
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increased susceptibility to xenobiotic induced morbidity/mortality
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:178054 Saha S, et al., PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe. 2009 Feb 19;5(2):137-50 |
| All: |
6 reference(s) |
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Analysis Tools
