Nkx2-2tm1Suss
Targeted Allele Detail
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| Symbol: |
Nkx2-2tm1Suss |
| Name: |
NK2 homeobox 2; targeted mutation 1, Lori Sussel |
| MGI ID: |
MGI:5297809 |
| Synonyms: |
Nkx2.2LCA |
| Gene: |
Nkx2-2 Location: Chr2:147019466-147036163 bp, - strand Genetic Position: Chr2, 72.63 cM, cytoband H
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| Germline Transmission: |
Unknown
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| Parent Cell Line: |
TL1/TL-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout, RMCE-ready) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment including exons 1 and 2 was replaced with a pUdeltaTK-EM7kan flanked by heterologous lox sites. This cassette is designed to facilitate recombinase mediated cassette exchange.
(J:177838, J:187468)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nkx2-2 Mutation: |
14 strains or lines available
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| Original: |
J:177838 Papizan JB, et al., Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming. Genes Dev. 2011 Nov 1;25(21):2291-305 |
| All: |
5 reference(s) |
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Analysis Tools
