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Scribtm1.1Phum
Targeted Allele Detail
Summary
Symbol: Scribtm1.1Phum
Name: scribbled planar cell polarity; targeted mutation 1.1, Patrick O Humbert
MGI ID: MGI:5299425
Synonyms: Scribfl
Gene: Scrib  Location: Chr15:75919011-75941633 bp, - strand  Genetic Position: Chr15, 35.29 cM
Alliance: Scribtm1.1Phum page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178461
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Flp-mediated recombination removed the neo cassette and left exons 4 through 13 floxed. (J:178461)
Generation of the Scribtm1.1Phum and Scribtm1.2Phum alleles
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
cn1  Disease Model
Krastm4Tyj/Kras+
Scribtm1.1Phum/Scribtm1.1Phum
involves: 129S4/SvJae
 
cn2  Disease Model
Krastm4Tyj/Kras+
Scribtm1.1Phum/Scrib+
involves: 129S4/SvJae
 
cn3  Disease Model
Krastm4Tyj/Kras+
Scribtm1.1Phum/Scribtm1.1Phum
Tg(Pbsn-cre)20Fwan/0
involves: 129S4/SvJae * FVB/NCrl
 
cn4
Krastm4Tyj/Kras+
Scribtm1.1Phum/Scrib+
Tg(Pbsn-cre)20Fwan/0
involves: 129S4/SvJae * FVB/NCrl
 
cn5
Scribtm1.1Phum/Scribtm1.1Phum
Tg(Pbsn-cre)20Fwan/0
involves: FVB/NCrl
 
Phenotypes:
Affected Systems
cn1
cn2
cn3
cn4
cn5
show or hide all annotated terms Sex:
     
digestive/alimentary system
√ √ √ √
abnormal intestine morphology
√ √ √ √
endocrine/exocrine glands
√ √ √
prostate gland hyperplasia
√ √
increased prostate gland adenocarcinoma incidence
√ √
increased prostate intraepithelial neoplasia incidence
√ √ √
abnormal prostate gland physiology
√ √ √
mortality/aging
√ √
premature death
√ √
neoplasm
√ √ √ √ √ √
increased prostate intraepithelial neoplasia incidence
√ √ √
increased carcinoma incidence
√ √
increased prostate gland adenocarcinoma incidence
√ √
increased lung tumor incidence
√ √
reproductive system
√ √ √
prostate gland hyperplasia
√ √
increased prostate gland adenocarcinoma incidence
√ √
increased prostate intraepithelial neoplasia incidence
√ √ √
abnormal prostate gland physiology
√ √ √
respiratory system
√ √
increased lung tumor incidence
√ √
lung epithelium hyperplasia
√
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
√ disease model   expected model not found
Models:
Human Diseases
cn1
cn2
cn3
IDs
 √ √
IDs
 √
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  54 strains or lines available
References
Original:  J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory