Hopx<tm2.1(cre/ERT2)Joe> Targeted Allele Detail MGI Mouse (MGI:5300731)

Hopx^{tm2.1(cre/ERT2)Joe}
Targeted Allele Detail

Summary

Symbol:	Hopx^{tm2.1(cre/ERT2)Joe}
Name:	HOP homeobox; targeted mutation 2.1, Jonathan A Epstein
MGI ID:	MGI:5300731
Synonyms:	Hopx^ERCre
Gene:	Hopx Location: Chr5:77234835-77262968 bp, - strand Genetic Position: Chr5, 41.45 cM
Alliance:	Hopx^{tm2.1(cre/ERT2)Joe} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:178296
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Hopx^{tm2.1(cre/ERT2)Joe} expression driven by 1 gene

Mutation details: An IRES-cre/ERT-Frt-PGK-neo-Frt cassette was inserted into the 3' UTR of the Hopx locus by homologous recombination in ES cells. Subsequently, these animals were crossed to mice expressing the Tg(ACTFLPe)9205Dym recombinase allele to remove the PGK-neo cassette. (J:178296)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hopx (mouse) Summary of all recombinase alleles driven by Hopx. Comparative matrix view of recombinase activities Alliance mouse Hopx gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Hopx Mutation:	11 strains or lines available

References

Original:	J:178296 Takeda N, et al., Interconversion between intestinal stem cell populations in distinct niches. Science. 2011 Dec 9;334(6061):1420-4
All:	37 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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