Tg(Sox10-icre/ERT2)26Vpa
Transgene Detail
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| Symbol: |
Tg(Sox10-icre/ERT2)26Vpa |
| Name: |
transgene insertion 26, Vassilis Pachnis |
| MGI ID: |
MGI:5301107 |
| Synonyms: |
SER26, Sox10::iCreERT2 |
| Transgene: |
Tg(Sox10-icre/ERT2)26Vpa Location: unknown
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| Alliance: |
Tg(Sox10-icre/ERT2)26Vpa page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Sox10-icre/ERT2)26Vpa expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Sox10 (MGI:98358) |
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Mutation details: The coding sequence of Sox10 in a phage artificial chromosome (PAC; RP21-529-16) was replaced with an icre/ERT2 cassette by homologous recombination in bacteria. The targeting vector also contained an Frt-flanked chloramphenicol resistance gene, which was removed by transient activation of Flp in bacteria. A construct was generated that encodes tamoxifen-inducible cre under control of the Sox10 regulatory sequences. The purified targeting construct was used to generate transgenic mice. These animals were crossed to ROSA26-EYFP reporter animals for analysis. Data for line 26 (SER26, [S]ox10::icre[ER]T2) was presented and was also confirmed by analysis of lines 68, 87 and 93.
(J:178239)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Sox10
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:178239 Laranjeira C, et al., Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest. 2011 Sep 1;121(9):3412-24 |
| All: |
30 reference(s) |
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Analysis Tools
