Cdkal1<tm1.1Tomik> Targeted Allele Detail MGI Mouse (MGI:5301441)

Cdkal1^tm1.1Tomik
Targeted Allele Detail

Summary

Symbol:	Cdkal1^tm1.1Tomik
Name:	CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa
MGI ID:	MGI:5301441
Synonyms:	Cdkal1^flox
Gene:	Cdkal1 Location: Chr13:29375729-30039657 bp, - strand Genetic Position: Chr13, 12.93 cM, cytoband A3.3
Alliance:	Cdkal1^tm1.1Tomik page

Endoplasmic reticulum distention in Cdkal1^tm1.2Tomik/Cdkal1^tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:178248
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. (J:178248)

Generation of the Cdkal1^tm1.1Tomik and Cdkal1^tm1.2Tomik alleles

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cdkal1 Mutation:	60 strains or lines available

References

Original:	J:178248 Wei FY, et al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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