Dll4tm2.1Vlcg
Targeted Allele Detail
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| Symbol: |
Dll4tm2.1Vlcg |
| Name: |
delta like canonical Notch ligand 4; targeted mutation 2.1, Velocigene |
| MGI ID: |
MGI:5302387 |
| Synonyms: |
Dll4COIN, Dll4i3COIN |
| Gene: |
Dll4 Location: Chr2:119156286-119166145 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
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| Alliance: |
Dll4tm2.1Vlcg page
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A conditional by inversion (COIN) intron consisting of a lox66_SA-Egpf-polyA_lox71 was inserted in the antisense orientation into intron 3 via homologous recombination, splitting intron 3 into 2 new exons (631 and 144 bp in length). The two lox sites are in reverse complementation orientation, thus cre-mediated recombination will irreversibly invert the inserted sequence. In addition, an FRT flanked hygromycin-delta-thymidine kinase cassette was inserted after the COIN intron. Flp-mediated recombination removed the hygromycin cassette.
(J:177797)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Dll4 Mutation: |
27 strains or lines available
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| Original: |
J:177797 Lobov IB, et al., The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow. Blood. 2011 Jun 16;117(24):6728-37 |
| All: |
3 reference(s) |
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Analysis Tools
