Pclaftm1.1Lkd
Targeted Allele Detail
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| Symbol: |
Pclaftm1.1Lkd |
| Name: |
PCNA clamp associated factor; targeted mutation 1.1, Lisa K Denzin |
| MGI ID: |
MGI:5302414 |
| Synonyms: |
Paf- |
| Gene: |
Pclaf Location: Chr9:65797519-65810548 bp, + strand Genetic Position: Chr9, 35.58 cM
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| Alliance: |
Pclaftm1.1Lkd page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:177782
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| Parent Cell Line: |
CY2.4 (ES Cell)
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| Strain of Origin: |
B6(Cg)-Tyrc-2J
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of the translation initiation site in exon 1. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette, 3' portion of exon 1 downstream of the translation initiation codon, intron 1, and exon 2. Western blot analysis confirmed the absence of protein expression in thymocytes.
(J:177782)
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Generation of the Pclaftm1.1Lkd allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pclaf Mutation: |
8 strains or lines available
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| Original: |
J:177782 Amrani YM, et al., The Paf oncogene is essential for hematopoietic stem cell function and development. J Exp Med. 2011 Aug 29;208(9):1757-65 |
| All: |
1 reference(s) |
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Analysis Tools
