Ccn6tm1(cre)Mawa
Targeted Allele Detail
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| Symbol: |
Ccn6tm1(cre)Mawa |
| Name: |
cellular communication network factor 6; targeted mutation 1, Matthew L Warman |
| MGI ID: |
MGI:5302829 |
| Synonyms: |
Wisp3GFP-Cre, Wisp3tm1(EGFP/cre)Mawa |
| Gene: |
Ccn6 Location: Chr10:39026966-39039790 bp, - strand Genetic Position: Chr10, 20.19 cM
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| Alliance: |
Ccn6tm1(cre)Mawa page
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| Allele Type: |
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Targeted (Recombinase) |
| Mutation: |
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Insertion
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Ccn6tm1(cre)Mawa expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: An EGFP-IRES-cre-construct was introduced to the first exon of Wisp3, retaining the gene's ATG translation initiation site. No full-length Wisp3 transcripts can be detected by RT-PCR.
Donating investigator indicates that expression of EGFP (enhanced green fluorescence protein) cannot be visualized by fluorescence microscopy. Hetero- and homozygous mice show no apparent phenotype. When males mutants are crossed with animals carrying a conditional (floxed) allele, cre-mediated recombination is observed in 100% of offspring. (Females occasionally also express cre in germ cells but at the precise stage is unclear. Cre-mediated recombination is observed in 7% of offspring from females.)There is little or no expression of cre in most other tissues examined, including muscle, kidney, bone, liver, and lung. Occasional recombination in brain, cartilage, and heart is seen.
(J:179652, J:201718)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Ccn6
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:179652 Warman ML, Generation of a knock-in cre recombinase allele of Wisp3. MGI Direct Data Submission. 2012; |
| All: |
3 reference(s) |
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Analysis Tools
