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Krt5tm1.1(cre/ERT2)Blh
Targeted Allele Detail
Summary
Symbol: Krt5tm1.1(cre/ERT2)Blh
Name: keratin 5; targeted mutation 1.1, Brigid L Hogan
MGI ID: MGI:5305438
Synonyms: K5-CreERT2, Krt5tm1.1Blh
Gene: Krt5  Location: Chr15:101615505-101621333 bp, - strand  Genetic Position: Chr15, 56.98 cM
Alliance: Krt5tm1.1(cre/ERT2)Blh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180048
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Krt5tm1.1(cre/ERT2)Blh expression driven by 1 gene
 
Mutation details: An IRES-cre/ERT2 fragment was inserted into the 3'UTR of the Krt5 gene along with an FRT flanked neomycin selection cassette. The selection cassette was subsequenty excised from properly targeted mice using flp recombinase. (J:180048)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Krt5 (mouse)
Summary of all recombinase alleles driven by Krt5.
 

Tumor Data
List all tumor models in MMHCdb carrying Krt5tm1.1(cre/ERT2)Blh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Krt5 Mutation:  13 strains or lines available
References
Original:  J:180048 Van Keymeulen A, et al., Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011 Nov 10;479(7372):189-93
All:  51 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory