Apc<tm1.1Alew> Targeted Allele Detail MGI Mouse (MGI:5305725)

Apc^tm1.1Alew
Targeted Allele Detail

Summary

Symbol:	Apc^tm1.1Alew
Name:	APC, WNT signaling pathway regulator; targeted mutation 1.1, Anabelle Lewis
MGI ID:	MGI:5305725
Synonyms:	APC^1322T
Gene:	Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
Alliance:	Apc^tm1.1Alew page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:180275
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Not Applicable)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A floxed neo cassette replaced the sequence corresponding to amino acids 1323 to 2845 and resulted in the deletion of all but one 20AAR domain with a truncation of the produced protein at 1322 (1322T). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 15. (J:180275)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1.1Alew

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Apc Mutation:	158 strains or lines available

References

Original:	J:180275 Pollard P, et al., The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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