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Is(2)46Ddu
Targeted Allele Detail
Summary
Symbol: Is(2)46Ddu
Name: insertion, Chr 2, Denis Duboule 46
MGI ID: MGI:5305737
Synonyms: HoxDrel5, rel5
Gene: Is(2)46Ddu  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178930
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsAbout 3 copies of an 11 kb Hoxd9/lacZ and floxed pgk-neo transgene construct were inserted into the rel5 position (chromosome 2: 74222892; Mouse Genome Assembly - NCBI build 36, mm8) via homologous recombination. This also resulted in duplication of most of the targeting sequence. Cre mediated recombination removed the neo cassette and additional Hoxd9/lacZ copies. LacZ expression is seen in the digits. (J:178930)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Is(2)46Ddu Mutation:  0 strains or lines available
References
Original:  J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory