About   Help   FAQ
Is(2)46Ddu
Targeted Allele Detail
Summary
Symbol: Is(2)46Ddu
Name: insertion, Chr 2, Denis Duboule 46
MGI ID: MGI:5305737
Synonyms: HoxDrel5, rel5
Gene: Is(2)46Ddu  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178930
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsAbout 3 copies of an 11 kb Hoxd9/lacZ and floxed pgk-neo transgene construct were inserted into the rel5 position (chromosome 2: 74222892; Mouse Genome Assembly - NCBI build 36, mm8) via homologous recombination. This also resulted in duplication of most of the targeting sequence. Cre mediated recombination removed the neo cassette and additional Hoxd9/lacZ copies. LacZ expression is seen in the digits. (J:178930)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Is(2)46Ddu Mutation:  0 strains or lines available
References
Original:  J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory