Tac2<tm1.1(cre)Qima> Targeted Allele Detail MGI Mouse (MGI:5307922)

Tac2^{tm1.1(cre)Qima}
Targeted Allele Detail

Summary

Symbol:	Tac2^{tm1.1(cre)Qima}
Name:	tachykinin 2; targeted mutation 1.1, Qiufu Ma
MGI ID:	MGI:5307922
Synonyms:	Tac2-Cre
Gene:	Tac2 Location: Chr10:127560347-127567637 bp, + strand Genetic Position: Chr10, 74.81 cM, cytoband D3
Alliance:	Tac2^{tm1.1(cre)Qima} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:180805
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Tac2^{tm1.1(cre)Qima} expression driven by 1 gene

Mutation details: The cre coding sequence with a poly adenylation signal was inserted in-frame with the first ATG of the Tac2 gene by homologous recombination. The initial targeting vector contained an Frt-flanked neomycin cassette. Germline-transmitting mice were crossed with a Flp deleter strain to excise the neo cassette. Insertion of the cre cassette results in generation of a null allele of Tac2 demonstrated by absence of Tac2 expression in the dorsal spinal cord as detected by in situ hybridization. (J:180805)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tac2 (mouse) Summary of all recombinase alleles driven by Tac2. Alliance mouse Tac2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Tac2 Mutation:	18 strains or lines available

References

Original:	J:180805 Mar L, et al., Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system. Mol Brain. 2012;5:3
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24