Ncr1<tm1.1(icre)Viv> Targeted Allele Detail MGI Mouse (MGI:5308410)

Ncr1^{tm1.1(icre)Viv}
Targeted Allele Detail

Summary

Symbol:	Ncr1^{tm1.1(icre)Viv}
Name:	natural cytotoxicity triggering receptor 1; targeted mutation 1.1, Eric Vivier
MGI ID:	MGI:5308410
Synonyms:	Cd335Cre, NKp46-cre, Nkp46^iCre, NKp46-iCre
Gene:	Ncr1 Location: Chr7:4340723-4348163 bp, + strand Genetic Position: Chr7, 2.5 cM
Alliance:	Ncr1^{tm1.1(icre)Viv} page

Generation of Ncr1^{tm1.1(icre)Viv}.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:180265
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Ncr1^{tm1.1(icre)Viv} expression driven by 1 gene

Mutation details: An IRES-icre-Frt-neo-Frt cassette was inserted at the 3' end of the Ncr1 (Nkp46) gene by homologous recombination. The resulting mice were crossed to an Flp expressing strain to excise the neo resistance cassette. (J:180265)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ncr1 (mouse) Summary of all recombinase alleles driven by Ncr1. Comparative matrix view of recombinase activities Alliance mouse Ncr1 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Ncr1 Mutation:	40 strains or lines available

References

Original:	J:180265 Narni-Mancinelli E, et al., Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18324-9
All:	119 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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