About   Help   FAQ
Cfap126tm1.1(icre)Heli
Targeted Allele Detail
Summary
Symbol: Cfap126tm1.1(icre)Heli
Name: cilia and flagella associated protein 126; targeted mutation 1.1, Heiko Lickert
MGI ID: MGI:5308442
Synonyms: 1700009P17Riktm1.1(icre)Heli, FltpT2AiCre
Gene: Cfap126  Location: Chr1:170941487-170954536 bp, + strand  Genetic Position: Chr1, 78.96 cM
Alliance: Cfap126tm1.1(icre)Heli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180887
Parent Cell Line:  IDG3.2 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Cfap126tm1.1(icre)Heli expression driven by 1 gene
 
Mutation details: A vector was constructed to insert a strept/FLAG-tandem affinity tag (SF-TAG) followed by a T2A peptide sequence (from Thosea asigna virus) and the codon-improved cre recombinase (icre) sequence into exon 6 of the 1700009P17Rik gene (called Flattop; Fltp). An Frt-flanked PGK-neo sequence followed cre in the construct. The targeting vector was introduced into IDG3.2 ES cells for homologous recombination. Southern blotting showed that recombination occurred on the C57BL/6J allele. After germline transmission was established, mice were crossed to Flpe-expressing line to remove the neo cassette. (J:180887)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cfap126 (mouse)
Summary of all recombinase alleles driven by Cfap126.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cfap126 Mutation:  15 strains or lines available
References
Original:  J:180887 Lange A, et al., Fltp(T2AiCre): A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues. Differentiation. 2012 Feb;83(2):S105-13
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory