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Mcph1tm1.1Zqw
Targeted Allele Detail
Summary
Symbol: Mcph1tm1.1Zqw
Name: microcephaly, primary autosomal recessive 1; targeted mutation 1.1, Zhao-Qi Wang
MGI ID: MGI:5308745
Synonyms: Mcph1delta
Gene: Mcph1  Location: Chr8:18645147-18853205 bp, + strand  Genetic Position: Chr8, 10.24 cM, cytoband A3
Alliance: Mcph1tm1.1Zqw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180706
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neo cassette was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 4 and 5 as well as the neo cassette. Western blot analysis confirmed the absence of protein expression in primary mouse embryonic fibroblasts and the brain. (J:180706)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcph1 Mutation:  58 strains or lines available
References
Original:  J:180706 Gruber R, et al., MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol. 2011 Nov;13(11):1325-34
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory