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Tg(Slc17a8-icre)1Edw
Transgene Detail
Summary
Symbol: Tg(Slc17a8-icre)1Edw
Name: transgene insertion 1, Robert H Edwards
MGI ID: MGI:5316477
Synonyms: VG3-Cre, VGLUT3 Cre BAC
Transgene: Tg(Slc17a8-icre)1Edw  Location: unknown  
Alliance: Tg(Slc17a8-icre)1Edw page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Slc17a8-icre)1Edw expression driven by 1 gene
 
Mutation details: The C57BL/6 mouse bacterial artificial chromosome (BAC) RP24-88H21, containing only the Slc17a8 locus, was modified by targeting a codon optimized cre recombinase (icre), followed by an SV40 polyA signal, into the ATG start site of theSlc17a8 locus. The modified BAC was microinjected into fertilized FVB/N oocytes and transgenic founders were obtained and crossed to mice expressing a cre-dependent reporter. Activity of icre is seen in interneurons in the hippocampus, cortex, striatum, and cerebellum, with some expression seen in amacrine cells of the inner retina. Two of four founder lines expressed cre, and one line was analyzed further. (J:182798)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc17a8 (mouse)
Summary of all recombinase alleles driven by Slc17a8.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:182798 Grimes WN, et al., Genetic targeting and physiological features of VGLUT3+ amacrine cells. Vis Neurosci. 2011 Sep;28(5):381-92
All:  37 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory