About   Help   FAQ
Slc26a5tm4.1(cre/ERT2)Jnz
Targeted Allele Detail
Summary
Symbol: Slc26a5tm4.1(cre/ERT2)Jnz
Name: solute carrier family 26, member 5; targeted mutation 4.1, Jian Zou
MGI ID: MGI:5316512
Synonyms: prestin-CreERT2-NN
Gene: Slc26a5  Location: Chr5:22015653-22070602 bp, - strand  Genetic Position: Chr5, 9.97 cM, cytoband A3
Alliance: Slc26a5tm4.1(cre/ERT2)Jnz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182720
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Slc26a5tm4.1(cre/ERT2)Jnz expression driven by 1 gene
 
Mutation details: A targeting vector was generated using recombineering methods to modify a BAC containing the Slc26a5 (prestin) locus. An IRES-cre/ERT2-frt-neo-frt cassette was inserted after the stop codon in exon 20. The vector was electroporated into TL-1 ES cells to produce knockin mice. Mice were crossed with Tg(ACTFlpe)9205Dym animals to delete the neo cassette. (J:182720)
Generation of Slc26a5tm4(cre/ERT2)Jnz and Slc26a5tm4.1(cre/ERT2)Jnz alleles.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc26a5 (mouse)
Summary of all recombinase alleles driven by Slc26a5.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc26a5 Mutation:  58 strains or lines available
References
Original:  J:182720 Fang J, et al., Outer hair cell-specific prestin-CreERT2 knockin mouse lines. Genesis. 2012 Feb;50(2):124-31
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory