Slc26a5tm4(cre/ERT2)Jnz
Targeted Allele Detail
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| Symbol: |
Slc26a5tm4(cre/ERT2)Jnz |
| Name: |
solute carrier family 26, member 5; targeted mutation 4, Jian Zou |
| MGI ID: |
MGI:5316514 |
| Synonyms: |
Prestin-CreERT2 |
| Gene: |
Slc26a5 Location: Chr5:22015653-22070602 bp, - strand Genetic Position: Chr5, 9.97 cM, cytoband A3
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| Alliance: |
Slc26a5tm4(cre/ERT2)Jnz page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:182720
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| Parent Cell Line: |
TL1/TL-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Slc26a5tm4(cre/ERT2)Jnz expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A targeting vector was generated using recombineering methods to modify a BAC containing the Slc26a5 (prestin) locus. An IRES-cre/ERT2-frt-neo-frt cassette was inserted after the stop codon in exon 20. The vector was electroporated into TL-1 ES cells to produce knockin mice. When crossed to EGFP reporter mice, cre activity was observed in outer hair cells in the cochlea at P2 with tamoxifen treatment at P0. No reporter signal could be detected in vestibular organs, testis or brain (tissues that express Slc26a5 at low levels.)
(J:182720)
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Generation of Slc26a5tm4(cre/ERT2)Jnz and Slc26a5tm4.1(cre/ERT2)Jnz alleles. |
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Slc26a5
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Slc26a5 Mutation: |
58 strains or lines available
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| Original: |
J:182720 Fang J, et al., Outer hair cell-specific prestin-CreERT2 knockin mouse lines. Genesis. 2012 Feb;50(2):124-31 |
| All: |
6 reference(s) |
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Analysis Tools
