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Tnfrsf11atm1(EGFP/cre)Ykob
Targeted Allele Detail
Summary
Symbol: Tnfrsf11atm1(EGFP/cre)Ykob
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, Yasuhiro Kobayashi
MGI ID: MGI:5316980
Synonyms: RANKCre, Tnfsrf11aCre
Gene: Tnfrsf11a  Location: Chr1:105708443-105775709 bp, + strand  Genetic Position: Chr1, 49.7 cM
Alliance: Tnfrsf11atm1(EGFP/cre)Ykob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181641
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Tnfrsf11atm1(EGFP/cre)Ykob expression driven by 1 gene
 
Mutation details: A cassette encoding an EGFP-cre fusion protein and an Frt-flanked neo/kanamycin cassette was inserted upstream of the endogenous STOP codon and downstream of the polyA sequences in the Tnfrsf11a1 gene by homologous recombination. The neo cassette was subsequently removed by crossing chimeras to CAG-FLPe mice. (J:181641)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tnfrsf11a (mouse)
Summary of all recombinase alleles driven by Tnfrsf11a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11a Mutation:  42 strains or lines available
References
Original:  J:181641 Maeda K, et al., Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med. 2012;18(3):405-12
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory