Foxa2<tm3.1(icre)Heli> Targeted Allele Detail MGI Mouse (MGI:5426440)

Foxa2^{tm3.1(icre)Heli}
Targeted Allele Detail

Summary

Symbol:	Foxa2^{tm3.1(icre)Heli}
Name:	forkhead box A2; targeted mutation 3.1, Heiko Lickert
MGI ID:	MGI:5426440
Synonyms:	Foxa2^T2AiCre, Foxa2^{tm1.1(icre)Hri}
Gene:	Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
Alliance:	Foxa2^{tm3.1(icre)Heli} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:184814
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Foxa2^{tm3.1(icre)Heli} expression driven by 1 gene

Mutation details: A targeting construct introduced a T2A sequence and a codon improved cre (icre) sequence with an Frt-flanked neo cassette into exon 3 of the Foxa2 locus. The neo was removed from the germline by Flp-e mediated excision. (J:184814)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa2 (mouse) Summary of all recombinase alleles driven by Foxa2. Comparative matrix view of recombinase activities Alliance mouse Foxa2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Foxa2 Mutation:	28 strains or lines available

References

Original:	J:184814 Horn S, et al., Mind bomb 1 is required for pancreatic beta-cell formation. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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