Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf
Transgene Detail
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| Symbol: |
Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf |
| Name: |
transgene insertion, Veronique Lefebvre |
| MGI ID: |
MGI:5426519 |
| Synonyms: |
ATC |
| Transgene: |
Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf Location: unknown
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| Alliance: |
Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase, Transactivator) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Acan |
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Mutation details: A bigenic construct was generated with a 0.9kb fragment of the Col2a1 promoter, 4 tandem copies of a cartilage-specific Acan enhancer in an intron, a splice acceptor site, the reverse tetracycline transactivator coding sequence and a polyadenylation site composing the first gene. A 4 kb Trp53 intron insulator sequence separated the rtTA sequence from the second part of the construct, consisting of a heptad of tandem copies of a tetracycline-responsive element (tetO), the human cytomegalovirus promoter (hCMV), the cre recombinase coding sequence, and a polyadenylation site. No founder information for the transgene is available. Upon treatment of transgenic mice with doxycycline, the rtTA is activated and binds to tetO to induce cre expression.
(J:183084)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Acan
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:183084 Dy P, et al., Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell. 2012 Mar 13;22(3):597-609 |
| All: |
11 reference(s) |
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Analysis Tools
