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Smarca1tm1.1Pick
Targeted Allele Detail
Summary
Symbol: Smarca1tm1.1Pick
Name: SNF2 related chromatin remodeling ATPase 1; targeted mutation 1.1, David J Picketts
MGI ID: MGI:5427348
Synonyms: Ex6DEL, Snf2l Ex6DEL
Gene: Smarca1  Location: ChrX:46898247-46981490 bp, - strand  Genetic Position: ChrX, 25.41 cM, cytoband A3.2
Alliance: Smarca1tm1.1Pick page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183998
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A floxed neo cassette was inserted upstream of exon 6 and a loxP site was inserted downstream of exon 6 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 6. The mutant allele produces a stable transcript and a protein product that is 7 kDa smaller than the wild-type protein. (J:183998)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarca1 Mutation:  12 strains or lines available
References
Original:  J:183998 Yip DJ, et al., Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain. Dev Cell. 2012 Apr 17;22(4):871-8
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory