Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Wnk4tm1Pfi
Name:	WNK lysine deficient protein kinase 4; targeted mutation 1, Pfizer, Ltd
MGI ID:	MGI:5427702
Gene:	Wnk4  Location: Chr11:101151393-101168235 bp, + strand  Genetic Position: Chr11, 64.51 cM
Alliance:	Wnk4tm1Pfi page

Germline Transmission:	Earliest citation of germline transmission: J:184790
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment, consisting of 75 bp 5' of exon 1, all of exon 1 and 737 bp 3' of exon 1, was replaced with a neo cassette via homologous recombination. Real time PCR and western blot analyses confirmed the absence of expression in homozygous mice. (J:184790)

Generation of the Wnk4tm1Pfi allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:	58 strains or lines available

Original:	J:184790 Castaneda-Bueno M, et al., Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7929-34
All:	12 reference(s)