Arap3tm1.2Sve
Targeted Allele Detail
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| Symbol: |
Arap3tm1.2Sve |
| Name: |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; targeted mutation 1.2, Sonja Vermeren |
| MGI ID: |
MGI:5428754 |
| Synonyms: |
Arap3- |
| Gene: |
Arap3 Location: Chr18:38105681-38132022 bp, - strand Genetic Position: Chr18, 19.85 cM
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| Alliance: |
Arap3tm1.2Sve page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:185401
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted in intron 5 and an FRT flanked neo cassette and loxP site were inserted in intron 8 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 6 - 8. Western blot analysis confirmed the absence of protein expression in yolk sac derived endothelial cells.
(J:185401)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Arap3 Mutation: |
61 strains or lines available
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| Original: |
J:185401 Gambardella L, et al., PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Sci Signal. 2010;3(145):ra76 |
| All: |
2 reference(s) |
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Analysis Tools
