Tg(Erv4-cre/ERT2*)657Slp
Transgene Detail
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| Symbol: |
Tg(Erv4-cre/ERT2*)657Slp |
| Name: |
transgene insertion 657, Samuel L Pfaff |
| MGI ID: |
MGI:5431581 |
| Synonyms: |
2C::ERT2-Cre-ERT2, Tg(MuERV-L-ERT2-Cre-ERT2)657Slp |
| Transgene: |
Tg(Erv4-cre/ERT2*)657Slp Location: unknown
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| Alliance: |
Tg(Erv4-cre/ERT2*)657Slp page
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| Strain of Origin: |
BALB/c and C57BL/6
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Erv4-cre/ERT2*)657Slp expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| virus |
Erv4 |
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Mutation details: The 5' LTR of murine endogenous retrovirus with leucine tRNA primer (MuERV-L; MERVL; Erv4) and the primer binding site drive expression of tamoxifen-inducible Cre recombinase (2C::ERT2-Cre-ERT2). Two flanking ERT2 segments were inserted to make Cre activation less leaky. The transgenic vector was injected into CB6 (BALB/c and C57BL/6) embryos and the resultant strain was subsequently maintained on the same mixed genetic background by the donating laboratory. This is founder line 657.
(J:186302)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Erv4
(virus)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:186302 Macfarlan TS, et al., Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature. 2012 Jul 5;487(7405):57-63 |
| All: |
1 reference(s) |
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Analysis Tools
