Neurog2<tm1(icre/ERT2*)Ggc> Targeted Allele Detail MGI Mouse (MGI:5431772)

Neurog2^{tm1(icre/ERT2*)Ggc}
Targeted Allele Detail

Summary

Symbol:	Neurog2^{tm1(icre/ERT2*)Ggc}
Name:	neurogenin 2; targeted mutation 1, Giacomo Consalez
MGI ID:	MGI:5431772
Synonyms:	Neurog2^CreER, Neurog2::ER^T2iCreER^T2, Neurog2^{tm1(icre/ERT2*)Fro}
Gene:	Neurog2 Location: Chr3:127426784-127429280 bp, + strand Genetic Position: Chr3, 56.54 cM, cytoband H1
Alliance:	Neurog2^{tm1(icre/ERT2*)Ggc} page

Mutation
origin

Mouse Generated:	Earliest citation of chimera generation: J:185504
Parent Cell Line:	v6.4 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Neurog2^{tm1(icre/ERT2*)Ggc} expression driven by 1 gene

Mutation details: A targeting construct was generated by homologous recombination in a BAC containing the Neurog2 gene. An ERT2iCreERT2 sequence (icre/ERT2*; codon inproved cre fused in-frame N- and C-terminally with mutated human estrogen receptors) was inserted into exon 2 of Neurog2, replacing the entire coding sequence. The construct was electroporated into ES cells for homologous recombination. (J:185504)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog2 (mouse) Summary of all recombinase alleles driven by Neurog2. Alliance mouse Neurog2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Neurog2 Mutation:	18 strains or lines available

References

Original:	J:185504 Florio M, et al., Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development. Development. 2012 Jul;139(13):2308-20
All:	7 reference(s)

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