Tg(Sox10-icre/ERT2)2Ldim
Transgene Detail
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| Symbol: |
Tg(Sox10-icre/ERT2)2Ldim |
| Name: |
transgene insertion 2, Leda Dimou |
| MGI ID: |
MGI:5431880 |
| Synonyms: |
2-Sox10 |
| Transgene: |
Tg(Sox10-icre/ERT2)2Ldim Location: unknown
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| Alliance: |
Tg(Sox10-icre/ERT2)2Ldim page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Sox10-icre/ERT2)2Ldim expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Sox10 (MGI:98358) |
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Mutation details: The bacterial artificial chromosome (BAC) RP23-28011 containing the Sox10 locus was modified to construct a transgene. A targeting vector containing the sequence for a codon improved cre recombinase (icre) fused cDNA encoding mutated estrogen receptor (ERT2), SV40 polyA sequence and an Frt-flanked PGK-neo cassette replaced exon 3 of the Sox10 gene in the BAC by homologous recombination in bacterial cells. Arabinose-induced Flpe expression removed the neo cassette. The purified transgene was microinjected into C57BL/6 oocyte pronuclei. Two founder lines, 1-Sox10 and 2-Sox10, were obtained. Line 1 was determined to have 2 copies of the transgene, and line 2, which showed higher expression, contained 9 copies.
(J:185481)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Sox10
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:185481 Simon C, et al., Sox10-iCreER(T2) : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage. Genesis. 2012 Jun;50(6):506-15 |
| All: |
1 reference(s) |
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Analysis Tools
