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Tg(Gcg-icre)12Fmgb
Transgene Detail
Summary
Symbol: Tg(Gcg-icre)12Fmgb
Name: transgene insertion 12, Fiona M Gribble
MGI ID: MGI:5432481
Synonyms: GLU-Cre12
Transgene: Tg(Gcg-icre)12Fmgb  Location: unknown  
Alliance: Tg(Gcg-icre)12Fmgb page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Gcg-icre)12Fmgb expression driven by 1 gene
 
Mutation details: The sequence for icre was inserted into a BAC (RP23-343C17) by recombineering techniques, replacing the sequence between the start codon in exon 2 of the Gcg (glucagon; proglucagon) locus and the stop codon in exon 6. The modified BAC was purified and injected into fertilized oocytes. Four founder lines were established initially and copy numbers were determined (line: 01, 7-8 copies; 12, 2-3; 14, 1; 30, 1). Line 12 was analyzed in detail in the publication. (J:186436)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gcg (mouse)
Summary of all recombinase alleles driven by Gcg.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:186436 Parker HE, et al., Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion. Diabetologia. 2012 Sep;55(9):2445-55
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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11/19/2024
MGI 6.24 		The Jackson Laboratory