Tg(Ednrb-icre)#Lby
Transgene Detail
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| Symbol: |
Tg(Ednrb-icre)#Lby |
| Name: |
transgene insertion, Patricia A Labosky |
| MGI ID: |
MGI:5432801 |
| Synonyms: |
Ednrb-iCre |
| Transgene: |
Tg(Ednrb-icre)#Lby Location: unknown
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| Alliance: |
Tg(Ednrb-icre)#Lby page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Ednrb-icre)#Lby expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Ednrb |
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Mutation details: The 1 kb Ednrb enhancer (from -1.2 kb to -160 bp upstream of start site) was combined with the Hspa1b (Hsp68) minimal promoter to drive expression of codon-improved cre recombinase (icre). Transgenic mice were generated by standard microinjection techniques. Founder information or line number was not available. Recombination specificity was verified by crossing this line to ROSA26-lacz reporter mice. Beta-galactosidase staining was first detected in the developing gastrointestinal (GI) tract at E11.0. At E11.5, recombination was observed in enteric neural-crest progenitors in the GI tract along the length from esophagus to cecum and in the neural tube, but not in other neural crest derivatives (heart, skin, cranial or dorsal ganglia>)
(J:182762)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Ednrb
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:182762 Mundell NA, et al., Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol. 2012 Mar 15;363(2):373-87 |
| All: |
1 reference(s) |
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Analysis Tools
