Tg(Col11a2-cre)1Ntsu
Transgene Detail
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| Symbol: |
Tg(Col11a2-cre)1Ntsu |
| Name: |
transgene insertion 1, Noriyuki Tsumaki |
| MGI ID: |
MGI:5435240 |
| Synonyms: |
11Enh-Cre, Col11a2prom-Cre-enh |
| Transgene: |
Tg(Col11a2-cre)1Ntsu Location: unknown
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| Alliance: |
Tg(Col11a2-cre)1Ntsu page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Col11a2-cre)1Ntsu expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Col11a2 |
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Mutation details: The cre sequence was inserted into a plasmid between the Col11a2 promoter (-742 to +380bp) and 2.3 kb of the first intron of Col11a2 which acts as an enhancer, replacing the beta-galactosidase (lacz) coding sequence. This construct was injected into fertilized ova to establish a transgenic line. Mice were crossed to reporter mice. At E14.5, cre recombination was observed in all chondrocytes (round, flat, prehypertrophic and hypertrophic chondrocytes) in the limbs and ribs.
(J:142326)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Col11a2
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:142326 Iwai T, et al., Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J Biol Chem. 2008 Oct 3;283(40):27154-64 |
| All: |
5 reference(s) |
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Analysis Tools
