Tg(Col11a2-cre)2Ntsu
Transgene Detail
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| Symbol: |
Tg(Col11a2-cre)2Ntsu |
| Name: |
transgene insertion 2, Noriyuki Tsumaki |
| MGI ID: |
MGI:5435242 |
| Synonyms: |
11Prom-Cre, Col11a2prom-Cre |
| Transgene: |
Tg(Col11a2-cre)2Ntsu Location: unknown
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| Alliance: |
Tg(Col11a2-cre)2Ntsu page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Col11a2-cre)2Ntsu expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Col11a2 |
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Mutation details: The cre sequence replaced the beta-galactosidase gene in a plasmid containing the Col11a2 promoter (-742 to +380bp). This construct was injected into fertilized ova to establish a transgenic line. Animals were crossed to reporter mice and at E14.5, cre activity was observed only in flat chondrocytes, prehypertrophic and hypertrophic chondrocytes in limbs and ribs, but not in round choncrocytes at the ends of each primordial cartilage. Some aberrant activity was observed in the forebrain at E12.5.
(J:142326)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Col11a2
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:142326 Iwai T, et al., Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J Biol Chem. 2008 Oct 3;283(40):27154-64 |
| All: |
3 reference(s) |
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Analysis Tools
