Col1a1<tm1(tetO-Deptor)Dmsa> Targeted Allele Detail MGI Mouse (MGI:5437855)

Col1a1^{tm1(tetO-Deptor)Dmsa}
Targeted Allele Detail

Summary

Symbol:	Col1a1^{tm1(tetO-Deptor)Dmsa}
Name:	collagen, type I, alpha 1; targeted mutation 1, David M Sabatini
MGI ID:	MGI:5437855
Synonyms:	iDeptor
Gene:	Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1^{tm1(tetO-Deptor)Dmsa} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:187378
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Mutation
description

Allele Type:

Targeted (Inducible, Inserted expressed sequence, RMCE-ready)

Inducer:

doxycycline/tetracycline

Mutation:

Insertion

Col1a1^{tm1(tetO-Deptor)Dmsa} expresses 1 gene

Col1a1^{tm1(tetO-Deptor)Dmsa} expression driven by 1 gene

Mutation details: Recombinase mediated cassette exchange in KH2 ES cells replaced the existing cassette at this locus with one encoding a tetO minimal promoter and Deptor coding sequence. (J:187378)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	163 strains or lines available

Notes

The allele was made in KH2 cells that carry Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} and Col1a1^{tm13(neo/hygro*)Jae}. This allele was generated with Col1a1^{tm13(neo/hygro*)Jae}.

References

Original:	J:187378 Laplante M, et al., DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity. Cell Metab. 2012 Aug 8;16(2):202-12
All:	2 reference(s)

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