Tg(Eno2-cre/Esr1*)778Vchl
Transgene Detail
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| Symbol: |
Tg(Eno2-cre/Esr1*)778Vchl |
| Name: |
transgene insertion 778, Vincent Chi Hang Lui |
| MGI ID: |
MGI:5438647 |
| Synonyms: |
NSE-MerCreMer |
| Transgene: |
Tg(Eno2-cre/Esr1*)778Vchl Location: unknown
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| Alliance: |
Tg(Eno2-cre/Esr1*)778Vchl page
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| Strain of Origin: |
(CBA x 129)F1
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Eno2-cre/Esr1*)778Vchl expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| rat |
Eno2 (24334) |
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Mutation details: The sequence of the rat NSE (neural specific enolase; Eno2) was inserted 5' upstream of cDNA encoding cre recombinase flanked by mutated mouse estrogen receptor ligand-binding domains (MerCreMer). The construct was injected into fertilized oocytes and 6 founders (4 male, 2 female) were generated and 2 (#'s 778 and 805) were found to show expression in the brain and intestine in F3 animals by RT-PCR or Western blot. The other 2 lines did not show protein expression in the brain or intestine despite MerCreMer transcript expression determined by RT-PCR. Transcript expression in line 778 was detected at E14.5, corresponding to neurogenesis in the CNS and ENS. Both lines were further characterized by analyses of tissue from offspring of crosses to reporter mice. Line 778 was created as a representative line.
(J:187253)
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Generation of Tg(Eno2-cre/Esr1*)778Vchl. |
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Eno2
(rat)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:187253 Kam MK, et al., Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons. PLoS One. 2012;7(5):e35799 |
| All: |
1 reference(s) |
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Analysis Tools
