Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Fgf10tm1.1(cre/ERT2)Sbel
Name:	fibroblast growth factor 10; targeted mutation 1.1, Saverio Bellusci
MGI ID:	MGI:5438701
Synonyms:	Fgf10Cre-ERT2, Fgf10iCre, Fgf10Ki-v1
Gene:	Fgf10  Location: Chr13:118851199-118928651 bp, + strand  Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
Alliance:	Fgf10tm1.1(cre/ERT2)Sbel page

Germline Transmission:	Earliest citation of germline transmission: J:187831
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Fgf10tm1.1(cre/ERT2)Sbel expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Fgf10 (MGI:1099809)   Mutation details: A targeting construct containing a cassette with the cre/ERT2 sequence followed by an IRES-YFP-polyA-neo fragment was injected into TVB2 ES cells. Homologous recombination intoduced the construct in frame with the ATG start codon of the Fgf10 exon 1. Chimeric animals were crossed to Flp-expressing mice to delete the neo selection cassette. It is a loss-of-function allele for Fgf10. (J:187831)

Generation of the Fgf10tm1.1(cre/ERT2)Sbel allele.

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf10 (mouse) Summary of all recombinase alleles driven by Fgf10. Alliance mouse Fgf10 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf10 Mutation:	33 strains or lines available

Original:	J:187831 El Agha E, et al., Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. PLoS One. 2012;7(6):e38452
All:	9 reference(s)