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Defb41tm1(icre)Psip
Targeted Allele Detail
Summary
Symbol: Defb41tm1(icre)Psip
Name: defensin beta 41; targeted mutation 1, Petra Sipila
MGI ID: MGI:5439010
Synonyms: DefbiCre
Gene: Defb41  Location: Chr1:18321204-18335362 bp, - strand  Genetic Position: Chr1, 5.7 cM, cytoband A4
Alliance: Defb41tm1(icre)Psip page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187838
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Defb41tm1(icre)Psip expression driven by 1 gene
 
Mutation details: cDNA encoding icr (improved cre) was inserted into the translation initiation site of the defensin beta 41 (Defb41) gene. icre is expressed in the proximal epididymis epithelium (in the initial segment, IS, and caput, CAP, of the epididymis). Full characterization of knockin mice will be published later. (J:187838)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Defb41 (mouse)
Summary of all recombinase alleles driven by Defb41.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Defb41 Mutation:  6 strains or lines available
References
Original:  J:187838 Bjorkgren I, et al., Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One. 2012;7(6):e38457
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory