Tg(Alpl-cre/ERT2)12Gcos
Transgene Detail
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| Symbol: |
Tg(Alpl-cre/ERT2)12Gcos |
| Name: |
transgene insertion 12, Giulio Cossu |
| MGI ID: |
MGI:5439469 |
| Synonyms: |
Tg:TN-AP-CreERT2 |
| Transgene: |
Tg(Alpl-cre/ERT2)12Gcos Location: unknown
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| Alliance: |
Tg(Alpl-cre/ERT2)12Gcos page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Alpl-cre/ERT2)12Gcos expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Alpl (MGI:87983) |
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Mutation details: Homologous recombination in bacterial cells inserted a construct with cre recombinase fused with the tamoxifen-responsive mutated estrogen receptor sequence, ERT2, into the ATG uptstream starting coding region of the tissue-nonspecific alkaline phosphatase gene (Alpl) in BAC clone RP23-400F8. The correctly targeted BAC was electroporated into fertilized eggs, producing seven founders. These were crossed to R26R reporter mice and three lines (3, 6, and 12) showed efficient cre recombination in progeny. Most subsequent experiments were performed with the line propagated from founder 12 which was more fertile than the other founders.
(J:188175)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Alpl
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:188175 Dellavalle A, et al., Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells. Nat Commun. 2011;2:499 |
| All: |
6 reference(s) |
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Analysis Tools
