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Gene Expression Data
Assay Details
Assay
Reference: J:120095 Donner AL, et al., Pax6 is misexpressed in Sox1 null lens fiber cells. Gene Expr Patterns. 2007 Apr;7(5):606-613
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5440424
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti PAX6 (DSHB)
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 1A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lens vesicle Present Regionally restricted 1A Authors report expression in all cells of the lens pit.

Specimen 1D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lens vesicle posterior epithelium Weak Regionally restricted 1D Decreased in intensity in the fiber cell compartment as compared to E11.5.
TS20: lens vesicle anterior epithelium Present 1D

Specimen 1G: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: posterior lens fiber Trace Regionally restricted 1G Expression further dowregulated; weakest expression in center of lens.
TS21: lens anterior epithelium Present 1G

Specimen 1J: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lens fiber Absent 1J No expression in fiber cell nuclei.
TS23: lens anterior epithelium Present 1J

Specimen 2A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lens vesicle posterior epithelium Weak Regionally restricted 2A Decreased expression in the fiber cell compartment compared to E11.5.

Specimen 2B: embryonic day 12.5; Sox1tm1Vep/Sox1tm2Vep (more )
Structure Level Pattern Image Note
TS20: lens vesicle Present 2B

Specimen 2C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lens Present 2C

Specimen 2D: embryonic day 13.5; Sox1tm1Vep/Sox1tm2Vep (more )
Structure Level Pattern Image Note
TS21: posterior lens fiber Present 2D Authors report inappropriate expression in posterior cells of the lens.

Specimen 2E: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lens fiber Absent 2E

Specimen 2F: embryonic day 15.5; Sox1tm1Vep/Sox1tm2Vep (more )
Structure Level Pattern Image Note
TS23: posterior lens fiber Present 2F Authors report inappropriate expression in posterior cells of the lens.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory