Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Ins2-Tag*,-flpe)#Gne
Name:	transgene insertion, Genentech
MGI ID:	MGI:5441546
Synonyms:	RIP-TbetaAg
Transgene:	Tg(Ins2-Tag*,-flpe)#Gne  Location: unknown
Alliance:	Tg(Ins2-Tag*,-flpe)#Gne page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inserted expressed sequence, Recombinase) Mutation:    Insertion   Tg(Ins2-Tag*,-flpe)#Gne expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Ins2 (24506) Ins2  (MGI:96573)   Mutation details: This transgene consists of 2 co-injected constructs. The first construct contains the rat insulin promoter followed by an SV40 T antigen in which the two exons are interrupted by an FRT flanked beta-globin intron. The second construct contains he rat insulin promoter followed by a flpe gene. Recombination and expression of the transgene is seen in the pancreas. Absence of recombination in the liver and spleen was confirmed by PCR analysis. (J:187012)

Activity:	Tissue activity of this recombinase allele
Driver:	Ins2 (rat) Summary of all recombinase alleles driven by Ins2. Alliance rat Ins2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:188693 Bagri A, et al., Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy. Clin Cancer Res. 2010 Aug 1;16(15):3887-900
All:	3 reference(s)