Tyr<c-Wtsi> Spontaneous Allele Detail MGI Mouse (MGI:5442732)

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Tyr^c-Wtsi
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Tyr^c-Wtsi
Name:	tyrosinase; albino Wellcome Trust Sanger Institute
MGI ID:	MGI:5442732
Gene:	Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
Alliance:	Tyr^c-Wtsi page

Mutation
origin

Mutant Cell Line:	EPD0176_3_A10
Germline Transmission:	Earliest citation of germline transmission: J:188986
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N

Mutation
description

Allele Type:		Spontaneous
Mutation:		Intragenic deletion Vector: L1L2_Bact_P
		Mutation details: The mutation is a 14.3 kb deletion of the tyrosinase gene spanning from 940 bp 5' of exon 1 (including the minimal promoter region) to 3.75 kb 3' of exon 2. This mutation arose spontaneously in EUCOMM embryonic stem (ES) cell clone EPD0176_3_A10, which was produced from JM8.N4 embryonic stem (ES) cells. (J:188986)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Tyr Mutation:	379 strains or lines available

References

Original:	J:188986 Ryder E, et al., An albino C57BL/6N mouse strain. MGI Direct Data Submission. 2012;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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