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Tyrc-Wtsi
Spontaneous Allele Detail
Summary
Symbol: Tyrc-Wtsi
Name: tyrosinase; albino Wellcome Trust Sanger Institute
MGI ID: MGI:5442732
Gene: Tyr  Location: Chr7:87073979-87142637 bp, - strand  Genetic Position: Chr7, 49.01 cM
Alliance: Tyrc-Wtsi page
Mutation
origin
Mutant Cell Line:  EPD0176_3_A10
Germline Transmission:  Earliest citation of germline transmission: J:188986
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation details: The mutation is a 14.3 kb deletion of the tyrosinase gene spanning from 940 bp 5' of exon 1 (including the minimal promoter region) to 3.75 kb 3' of exon 2. This mutation arose spontaneously in EUCOMM embryonic stem (ES) cell clone EPD0176_3_A10, which was produced from JM8.N4 embryonic stem (ES) cells. (J:188986)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  379 strains or lines available
References
Original:  J:188986 Ryder E, et al., An albino C57BL/6N mouse strain. MGI Direct Data Submission. 2012;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory