Et(cre)TFC.09Lois
Transgene Detail
|
|
| Symbol: |
Et(cre)TFC.09Lois |
| Name: |
enhancer trap TFC.09, Carlos Lois |
| MGI ID: |
MGI:5443915 |
| Transgene: |
Et(cre)TFC.09Lois Location: unknown Genetic Position: ChrX, Syntenic
|
| Alliance: |
Et(cre)TFC.09Lois page
|
|
|
|
| Transgene Type: |
|
Transgenic (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Et(cre)TFC.09Lois expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Et(cre)TFC.09Lois (MGI:5443913) |
|
|
| |
|
Mutation details: Injection of a lentiviral vector carrying an enhancer trap detector cassette composed of Cre::GFP fusion gene under control of the mouse Thy1.2 minimal promoter (129 bp) was used to generate several cre lines. These were crossed with Z/EG reporter mice, and the patterns of GFP labeling in the brains of the offspring were examined. One line, TCF.09, displayed a low rate of recombination in a sparse and seemingly random subset of neural precursors during development. A single copy of the transgene integrated into the seventh intron of the glypican-3 gene; recombination activity showed no correlation with endogenous Gpc3 gene expression. The investigator reports that GFP expression is almost undetectable by fluorescence and it is only transiently expressed in a few stem cells in the embryo.
(J:188479)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Et(cre)TFC.09Lois
(mouse)
|
| |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
| Original: |
J:188479 Magavi S, et al., Coincident generation of pyramidal neurons and protoplasmic astrocytes in neocortical columns. J Neurosci. 2012 Apr 4;32(14):4762-72 |
| All: |
2 reference(s) |
|
Analysis Tools
