Sftpctm1(cre/ERT2,rtTA)Hap
Targeted Allele Detail
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| Symbol: |
Sftpctm1(cre/ERT2,rtTA)Hap |
| Name: |
surfactant associated protein C; targeted mutation 2, Harold A Chapman |
| MGI ID: |
MGI:5444645 |
| Synonyms: |
SPCcre-ER |
| Gene: |
Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
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| Alliance: |
Sftpctm1(cre/ERT2,rtTA)Hap page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:175915
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129 and C57BL/6
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| Allele Type: |
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Targeted (Inducible, Recombinase, Transactivator) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Sftpctm1(cre/ERT2,rtTA)Hap expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Sftpc (MGI:109517) |
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Mutation details: The terminal stop codonin exon 5 of the endogenous mouse gene was replaced with an estrogen-dependent cre cDNA (creERT2) preceded in frame by a E2A peptide sequence to interrupt translation between SPC and cre mRNAs coexpressed on a single transcript and followed by a T2A peptide sequence and rtTA. This was then followed by an Frt flanked neo selection cassette.
(J:175915)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Sftpc
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Sftpc Mutation: |
24 strains or lines available
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Targeting was accomplished in 129/C57bl6 hybrid ES cells (iGeniousTL, Inc., Stony Brook, NY).
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| Original: |
J:175915 Chapman HA, et al., Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul 1;121(7):2855-62 |
| All: |
49 reference(s) |
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Analysis Tools