Tg(Tyrp1-cre/ERT2)1Mtz
Transgene Detail
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| Symbol: |
Tg(Tyrp1-cre/ERT2)1Mtz |
| Name: |
transgene insertion 1, Daniel Metzger |
| MGI ID: |
MGI:5446622 |
| Synonyms: |
TRP1-Cre-ERT2 |
| Transgene: |
Tg(Tyrp1-cre/ERT2)1Mtz Location: unknown
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| Alliance: |
Tg(Tyrp1-cre/ERT2)1Mtz page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Tyrp1-cre/ERT2)1Mtz expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Tyrp1 |
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Mutation details: A 4.4 kb DNA fragment encompassing the Tyrp1 promoter region was cloned into a vector containing the cre/ERT2 sequence. The resulting 7.3 kb construct was purified for microinjection into oocytes and 4 founder lines were generated. Animals from these lines were crossed to mice carrying floxed alleles. Double transgenic offspring were treated with tamoxifen and recombination activity was assessed. One line demonstrated recombination in the pigmented retinal epithelium, but no activity in non-ocular tissues. This line was examined in greater detail.
(J:189533)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Tyrp1
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:189533 Mori M, et al., Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium. Genesis. 2012 Nov;50(11):828-32 |
| All: |
1 reference(s) |
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Analysis Tools
