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Pank2tm1.1Suja
Targeted Allele Detail
Summary
Symbol: Pank2tm1.1Suja
Name: pantothenate kinase 2; targeted mutation 1.1, Suzanne Jackowski
MGI ID: MGI:5446719
Gene: Pank2  Location: Chr2:131104415-131141108 bp, + strand  Genetic Position: Chr2, 63.31 cM
Alliance: Pank2tm1.1Suja page
Small size of Pank1tm1.1Suja/Pank1tm1.1Suja Pank2tm1.1Suja/Pank2tm1.1Suja mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189609
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A floxed allele was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exon 3. Total PanK enzyme activity was reduced 30% in the liver and 90% in the brain. (J:189609)
Creation of the Pank2tm1.1Suja allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pank2 Mutation:  35 strains or lines available
References
Original:  J:189609 Garcia M, et al., Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism. PLoS One. 2012;7(7):e40871
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory