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Pitx3tm1(icre)Smdt
Targeted Allele Detail
Summary
Symbol: Pitx3tm1(icre)Smdt
Name: paired-like homeodomain transcription factor 3; targeted mutation 1, Marten P Smidt
MGI ID: MGI:5447644
Synonyms: Pitx3-Cre
Gene: Pitx3  Location: Chr19:46124124-46136765 bp, - strand  Genetic Position: Chr19, 38.75 cM
Alliance: Pitx3tm1(icre)Smdt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189656
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Pitx3tm1(icre)Smdt expression driven by 1 gene
 
Mutation details: A sequence ('exon') containing the En2 splice acceptor, an IRES-improved cre (icre)-SV40-polyA, and a hygromycin-TK selection cassette was inserted into the Pitx3 locus, replacing a part of the coding region, by homologous recombination in ES cells. (J:189656)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pitx3 (mouse)
Summary of all recombinase alleles driven by Pitx3.
 

Expression
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx3 Mutation:  22 strains or lines available
References
Original:  J:189656 Smidt MP, et al., Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model. PLoS One. 2012;7(8):e42641
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory