About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:138305 Meyer KD, et al., Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr Patterns. 2008 Sep;8(7-8):494-501
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5449036
Gene symbol: Disc1
Gene name: disrupted in schizophrenia 1
Antibody: anti-DISC1 Mid
Assay notes: Authors state that both Disc1 Mid (MGI:5449001) and Disc1 Cterm (MGI:5449004) antibodies were used for all experiments and gave identical expression patterns at all ages tested. (See assay MGI:5449042.)
Results
Specimen 2A: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: hippocampus Present Widespread 2A Robust expression throughout the hippocampus. Expression in granule cells precursors moving toward the dentate gyrus.

Specimen 2B: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: hippocampus CA3 Present 2B

Specimen 2C: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: dentate gyrus Present 2C

Specimen 2E: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: hippocampus CA3 Present 2E

Specimen 2F: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: dentate gyrus Present 2F

Specimen 2G: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: hippocampus Present Regionally restricted 2G Well-defined expression pattern in Ammon's horn and the dentate gyrus.

Specimen 2H: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Present Regionally restricted 2H Well-defined expression pattern in Ammon's horn and the dentate gyrus.

Specimen 2I: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Regionally restricted 2I Well-defined expression pattern in Ammon's horn and the dentate gyrus.

Specimen 2J: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: hippocampus Present Regionally restricted 2J Well-defined expression pattern in Ammon's horn and the dentate gyrus.

Specimen 2K: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Present Regionally restricted 2K Well-defined expression pattern in Ammon's horn and the dentate gyrus.

Specimen 2L: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Regionally restricted 2L Well-defined expression pattern in Ammon's horn and the dentate gyrus.

Specimen 3A/C: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present 3A , 3C Expression in mature granule cells of the dentate gyrus.

Specimen 3D/F: postnatal week 6 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present 3D , 3F Expression in mature granule cells of the dentate gyrus.

Specimen 3G/I: postnatal adult (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Regionally restricted 3G , 3I No expression in granule cell mossy fibers (axons).

Specimen 4A/C: postnatal week 14 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present 4A , 4C No expression in granule cell mossy fibers (axons).

Specimen 5A/C: postnatal week 10 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Regionally restricted 5A , 5C Expression in interneurons at the base of the granule cell layers.

Specimen 5D/F: postnatal week 10 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Present Regionally restricted 5F , 5D Expression in interneurons located in the CA1 stratum oriens.
TS28: hippocampus stratum oriens Present Regionally restricted 5F , 5D Expression in interneurons located in the CA1 stratum oriens.

Specimen 6A: postnatal week 10 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present 6A

Specimen 6B: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Present Regionally restricted 6B Expression in CA3 pyramidal neurons in a distinct perinuclear pattern, extending slightly into the proximal region of dendrites.
TS28: hippocampus pyramidal cell layer Present Regionally restricted 6B Expression in CA3 pyramidal neurons in a distinct perinuclear pattern, extending slightly into the proximal region of dendrites.

Specimen 6C: postnatal week 14 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Present Regionally restricted 6C Expression in CA3 pyramidal neurons in a distinct perinuclear pattern. Authors state that much of the expression in dendritic extensions is lost.
TS28: hippocampus pyramidal cell layer Present Regionally restricted 6C Expression in CA3 pyramidal neurons in a distinct perinuclear pattern. Authors state that much of the expression in dendritic extensions is lost.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
09/17/2024
MGI 6.24
The Jackson Laboratory