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Gene Expression Data
Assay Details
Assay
Reference: J:138305 Meyer KD, et al., Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr Patterns. 2008 Sep;8(7-8):494-501
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5449042
Gene symbol: Disc1
Gene name: disrupted in schizophrenia 1
Antibody: anti-DISC1 Cterm
Assay notes: Authors state that both Disc1 Mid (MGI:5449001) and Disc1 Cterm (MGI:5449004) antibodies were used for all experiments and gave identical expression patterns at all ages tested. (See assay MGI:5449036.)
Results
Specimen 2D: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: dentate gyrus Present Widespread 2D Slightly better defined pattern in Ammon's horn and in the forming blades of the dentate gyrus. Expression in granule cell precursors moving toward the dentate gyrus.
TS27: hippocampus Present Widespread 2D Slightly better defined pattern in Ammon's horn and in the forming blades of the dentate gyrus. Expression in granule cell precursors moving toward the dentate gyrus.

Specimen 2M: postnatal day 30 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Strong 2M
TS28: hippocampus CA2 Strong 2M
TS28: hippocampus CA3 Strong 2M

Specimen 2N: postnatal day 30 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Strong 2N

Specimen 2O: postnatal day 30 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 2O

Specimen 2P: postnatal week 18 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Weak 2P Decreased expression in the CA1.

Specimen 2Q: postnatal week 18 (more )
Structure Level Pattern Image Note
TS28: hippocampus CA3 Strong 2Q

Specimen 2R: postnatal week 18 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Strong 2R

Specimen 4D/F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Regionally restricted 4F , 4D Expression in early postmitotic granule cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/17/2024
MGI 6.24
The Jackson Laboratory